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KMID : 1134820160450060918
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 6 p.918 ~ p.922
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Antioxidant and Anti-Proliferative Activities of Oats under Different Solvent Extraction Conditions
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Ham Hyeon-Mi
Woo Koan-Sik
Park Ji-Young
Lee Byong-Won
Choi Yong-Hwan
Lee Choon-Wo
Kim Uk-Han
Lee Jun-Soo
Lee Yu-Young
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Abstract
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The objective of this study was to determine the antioxidant and anti-proliferative activities of methanol, ethanol, acetone, and ethyl acetate extracts from oats (Avena sativa L.). Total polyphenol contents of extracts were analyzed by Folin-Ciocalteu assay. The antioxidant activities of extracts were determined by 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities and reducing power. The anti-proliferative activities of colon (HCT116), lung (NCI-H460), and breast (MCF7) cancer cells were investigated. Among solvents, methanol extract showed the highest amount of total polyphenols, which was 8.2 mg gallic acid equivalents/g residue. High levels of ABTS radical [12.1 mg Trolox equivalent antioxidant capacity (TEAC)/g residue] and DPPH radical (4.4 mg TEAC/g residue) scavenging activity and reducing power (A700=0.39) were found in methanol extracts. Moreover, methanol extracts indicated higher anti-proliferative activities against HCT116 (69.5%), NCI-H460 (75.2%), and MCF7 (84.8%) cells compared with other extracts. The results show that methanol was the best solvent for extraction of antioxidant and anti-proliferative compounds from oats. Moreover, notable antioxidant and anti-proliferative activities of oats could have significant health benefits.
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KEYWORD
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oat, polyphenolics, antioxidant, antiproliferation
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